FatalPneumocystis pneumonia from ACTH therapy for infantile spasms

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Fatal Pneumocystis pneumonia from ACTH therapy for infantile spasms.

cautiously. Only a few relatives have been examined , and therefore ascertainment of the correct diagnosis by history alone is difficult. Increased heritability in PD is suggested by the occasional occurrence of PD in large kindreds and in monozygotic twins [4]. We and others have provided evidence that a subgroup of PD patients, particularly those with prominent tremor, have a genetic suscepti...

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ACTH therapy in infantile spasms: side effects.

162 children with infantile spasms were treated with ACTH at the Children's Hospital, Helsinki, and at the Aurora Hospital, Helsinki, during 1960--76. In a large proportion (37%) of the children the treatment caused pronounced side effects, and the mortality was 4.9%. The most common complications were infections: septic infections, pneumonias, and urinary and gastrointestinal infections. Other...

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Observations in Children with Infantile Spasms Treated with Acth

The treatment of children suffering from the type of seizure which is part of the syndrome of infantile spasms has been disappointing since 1841. At this time Dr. W. J. West first described the attacks in his own son and was treating the child with leeches, calomel purgatives, and gum lancing. Though these measures and the others used in the cases later described by Newnham (-1849) may seem biz...

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Vigabatrin versus ACTH in the treatment of infantile spasms.

OBJECTIVE To compare adrenocorticotropic hormone with vigabatrin as a single mono-therapy for infantile spasms. We studied hospitalization time, clinical response, whether complete or partial, time taken for improvement, and presence or absence of recurrence after stopping the medication. Together with improvement of electroencephalographic changes, and time taken for significant response, neur...

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Infantile spasms.

Infantile spasms constitute both a distinctive seizure type and an age-specific epilepsy syndrome that have been extensively described for over a century. Standardization of the classification of infantile spasms has evolved, culminating in recent recommendations for separately recognizing and distinguishing the seizure type (spasms or epileptic spasms) and the epilepsy syndrome of infantile sp...

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ژورنال

عنوان ژورنال: Annals of Neurology

سال: 1986

ISSN: 0364-5134,1531-8249

DOI: 10.1002/ana.410190320